pretomanid pronunciation

Take your next dose at the regular time. The manufacturer directs to swallow this medication whole. However, having tuberculosis during pregnancy may cause serious complications in both the mother and the baby. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. However, many similar drugs (immediate-release tablets) can be split/crushed. Your doctor or pharmacist can provide more information about pretomanid. • Hepatic effects: Hepatic adverse reactions have been reported with pretomanid in combination with bedaquiline and linezolid. During the first 2 weeks, all 3 medications are taken daily. Consult drug interactions database for more detailed information. Discuss the risks and benefits with your doctor. Do not drink alcohol while taking this antibiotic combination. Your doctor may occasionally change your dose, or tell you to stop using the medicines. Note: This is not a comprehensive list of all side effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Consult your doctor before breast-feeding. If your doctor tells you to stop taking the antibiotic combination, follow all instructions for taking the missed doses at the end of your treatment. pronouncekiwi - How To Pronounce Pretomanid. Pretomanid … Pretomanid is an antimycobacterial drug that kills actively replicating Mycobacterium tuberculosis by inhibiting mycolic acid biosynthesis, blocking cell wall production. Also see bedaquiline and linezolid monographs. Last updated on Apr 12, 2020. Conditions of use: The information in this database is intended to supplement, not substitute for the expertise and judgment of healthcare professionals. Store <30°C (86°F). Monitor therapy, Sarilumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).

Have a fact about Pretomanid ? Tuberculosis: Treatment of pulmonary extensively drug resistant or treatment-intolerant or nonresponsive multidrug-resistant tuberculosis (TB), as part of a combination regimen with bedaquiline and linezolid, in adult patients.

Version: 1.01. Pretomanid is an antibiotic used in combination with bedaquiline and linezolid to treat extensively drug-resistant tuberculosis in adults. Pretomanid belongs to a class of drugs known as antibiotics. Many people using this medication do not have serious side effects. When linezolid dosing, as part of this combination regimen, was reduced, interrupted, or discontinued, the hematologic abnormalities were reversible. For the best effect, take this antibiotic at evenly spaced times. Avoid combination, CYP3A4 Inducers (Moderate): May decrease the serum concentration of Pretomanid. Keep all medical and lab appointments. Many drugs can affect pretomanid. long QT syndrome (in you or a family member); low levels of calcium, potassium, or magnesium in your blood. This medicine will not treat tuberculosis that is not active (latent), or tuberculosis that affects parts of the body other than the lungs. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Swallow the tablet whole and do not crush, chew, or break it. Monitor visual function. Revision date: 12/4/2019. Learn how we develop our content. Obtain serum calcium, magnesium, and potassium at baseline; correct if abnormal and repeat testing if QT prolongation occurs. Oral: Administer with food. Do not change your dose or dosing schedule without your doctor's advice. Swallow tablet whole with water. • Neuropathy: Peripheral and optic neuropathy have been reported with pretomanid in combination with bedaquiline and linezolid. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. It is unknown if this drug passes into breast milk. This medication has been prescribed for your current condition only.

Adverse events were observed in some animal reproduction studies.

Sometimes it is not safe to use certain medications at the same time.

Keep the bottle tightly closed when not in use. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Neuropathy is a known adverse reaction of long-term linezolid use that is generally reversible or improved with appropriate monitoring and interruption, dose reduction, or discontinuation of linezolid. Monitor therapy, Siltuximab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). Lab and/or medical tests (such as complete blood counts, liver function, EKG, potassium/calcium/magnesium levels, eye exams) should be done before you start taking this medication and while you are taking it. Examples include efavirenz, rifamycins (such as rifampin, rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others. We comply with the HONcode standard for trustworthy health information -, Drug class: miscellaneous antituberculosis agents. Do not double the dose to catch up.

During pregnancy, this medication should be used only when clearly needed. For help between 5 p.m. and 9 a.m., call 1-800-332-1414 and press 2 for the Medication and Herbal Preparation Advice Line.
Call your doctor for medical advice about side effects. The benefit of treating tuberculosis may outweigh any risks to the baby. If you keep this medicine at home, store it in the original container at room temperature, away from moisture and heat. • Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy.

Pretomanid is not approved for use by anyone younger than 18 years old. Follow your doctor's instructions very carefully. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. Obtain an ECG prior to initiation of treatment and ≥2, 12, and 24 weeks after starting treatment, or if syncope occurs. Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: This medication, taken with certain other TB medications, can commonly cause a rash that is usually not serious. Available for Android and iOS devices. This information is not specific medical advice and does not replace information you receive from the healthcare provider. Copyright 1996-2020 Cerner Multum, Inc. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Pretomanid is used in combination with bedaquiline and linezolid; refer to the bedaquiline and linezolid monographs for additional information. Frequently reported side effects of this drug. Pretomanid is taken with food and a glass of water. Follow all instructions very carefully.

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Avoid alcohol and hepatotoxic agents, especially in patients with impaired hepatic function. Monitor patients for signs and symptoms of hepatotoxicity (eg, anorexia, dark urine, elevations in liver function tests, fatigue, hepatomegaly, jaundice, liver tenderness, nausea); if new or worsening hepatic dysfunction occurs, test for viral hepatitides and discontinue other hepatotoxic medications. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Monitor CBC and consider decreasing or interrupting linezolid dosing in patients who develop or have worsening myelosuppression. This information does not replace the advice of a doctor. Nausea, upset stomach, diarrhea, cough, muscle/joint pain, acne, and headache may occur. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Alberta residents can call PADIS (Poison and Drug Information Service) 24 hours a day at 1-800-332-1414.

Tablet, Oral: Generic: 200 mg

Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Obtain an ECG prior to initiation of treatment and ≥2, 12, and 24 weeks after starting treatment. Treatment may be extended beyond 26 weeks if necessary. Always ask your health care professional for complete information about this product and your specific health needs. This antibiotic treats only bacterial infections. Listen to the audio pronunciation of Pretomanid on pronouncekiwi.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Alcohol may increase the risk of liver disease. Urine: 53% (primarily metabolites [~1% as unchanged drug]); Feces: 38%. If any of these effects last or get worse, tell your doctor or pharmacist promptly. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Learn how we develop our content. This medicine may affect fertility (ability to have children) in men. • Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. Read the Medication Guide provided by your pharmacist before you start taking pretomanid and each time you get a refill. Avoid combination, CYP3A4 Inducers (Strong): May decrease the serum concentration of Pretomanid. Use your medications for the full prescribed length of time, even if your symptoms quickly improve. Thank you for helping build the largest language community on the internet.

It works by stopping the growth of the bacteria that causes TB. Do not use it later for another infection unless your doctor tells you to. Missed doses: If the combination regimen of pretomanid, bedaquiline, and linezolid is interrupted by a health care provider for safety reasons, missed doses may be made up at the end of the treatment. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. You may need to take this drug combination while being observed by a healthcare professional. US residents can call their local poison control center at 1-800-222-1222. Myelosuppression is a known adverse reaction of linezolid. Pretomanid, bedaquiline, and linezolid are usually given for a total of 26 weeks. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. This is not a complete list of side effects and others may occur. Pronunciation: pre-TOE-ma-nid. Other medications can affect the removal of pretomanid from your body, which may affect how pretomanid works.

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