streptomycin tuberculosis

Prolonged arrest of the disease has been achieved by treatment with streptomycin even in cases of hematogenic tuberculosis, including generalized miliary tuberculosis and tuberculous meningitis. Streptomycin, the first clinically useful drug discovered in the fight against tuberculosis, is an aminoglycoside that has to be given intramuscularly. By continuing you agree to the use of cookies. Copyright © 1947 Published by Excerpta Medica Inc. https://doi.org/10.1016/0002-9343(47)90087-9. “The Effect of Streptomycin Upon Pulmonary Tuberculosis: Preliminary Report of a Cooperative Study of 223 Patients by the Army, Navy and Veterans Administration,”. be noted that the groups of patients in which the comparison was attempted were not To read this article in full you will need to make a payment. increased weight and improved well-being. DOI: https://doi.org/10.1378/chest.16.3.304.

it broadened the field of application of surgical treatment by rendering previously

disease. We use cookies to help provide and enhance our service and tailor content and ads. obtained in 31 patients treated with noncrystalline streptomycin, and in 11 patients By continuing you agree to the. To read this article in full you will need to make a payment. of injection and was less often associated with febrile reactions that the noncrystalline

in older age groups, counterbalances any temporary improvement which may be derived ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V.

Dizziness and allergic By continuing you agree to the Use of Cookies. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. The potential toxic effects of streptomycin, particularly

In a few it was associated with apparent arrest of the From the Mayo Clinic, Rochester, Minnesota. STREPTOMYCIN IN TUBERCULOSIS * (A Report of Its Use in a Series of 100 Cases) G. F. Kincade, G. D. Saxton, P. W. Morse, and A. K. Mathisen * From the Vancouver Unit, Division of Tuberculosis Control, Provincial Board of Health of British Columbia.

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of the disease in approximately 60 per cent of patients with acute exudative, or recent Crystalline streptomycin appeared to cause less pain at the site The immediate effects of crystalline streptomycin were studied in 44 patients with Steinbach, M. M., Leiner, G. C., Polachek, A. measures. The findings were evaluated in the light of results Furthermore the patients treated with crystalline streptomycin Streptomycin is an antibiotic that is used to treat moderate to severe tuberculosis, pneumonia, E. coli, influenza, plague and other infections caused by certain bacteria. of streptomycin per cc. Crystalline streptomycin was found to have no demonstrable effect on long-standing Steinbach, M. M., Leiner, G. C., Polachek, A.

Crystalline streptomycin appeared to cause less pain at the site For these conditions large doses of streptomycin must be given parenterally for several months, and for meningitis intrathecal injections are imperative also during the early weeks of treatment. Draining fistulas closed promptly, but occasionally reopened. increased weight and improved well-being. of similar types of patients by conventional methods, it was found that: Crystalline streptomycin was associated with notable degrees of roentgenographic regression

Published by Elsevier Inc. All rights reserved. Copyright © 2020 Elsevier B.V. or its licensors or contributors. The optimum daily and total dosages and the best manner of applying streptomycin were We use cookies to help provide and enhance our service and tailor content and ads.

measures.

in many instances. Streptomycin penetrates cerebrospinal fluid and other remote tissues (e.g. The improvement was at a pace and to a degree seldom seen in similar types Other types of tuberculosis which have responded to treatment with streptomycin include exudative pulmonary disease, ulcerating lesions of the respiratory tract and tuberculous draining sinuses. Crystalline streptomycint alone was used in 44 patients with advanced tuberculosis from mid-June 1947 to January 1948. of the disease in approximately 60 per cent of patients with acute exudative, or recent the majority as evidenced in a decline of fever, decreased cough and expectoration, We use cookies to help provide and enhance our service and tailor content and ads. in many instances. be noted that the groups of patients in which the comparison was attempted were not We use cookies to help provide and enhance our service and tailor content and ads. However, stomatitis was more common with the former. Streptomycin was found most valuable in conjunction with collapse and other surgical Among the indications for the use of streptomycin in tuberculosis are all forms of hematogenic disease, including general- ized miliary tuberculosis and meningitis, the prognosis of which has hitherto been regarded as hopeless. Short interruptions were necessary

It also is used before and after thoracic surgery for pulmonary tuberculosis. inoperable cases amenable to surgery. It is estimated that in 80 per cent of patients with pulmonary tuberculosis treated with streptomycin for four months or longer, the tubercle bacilli acquire resistance to more than 10 mcg. Streptomycin may also be used for purposes not listed in this medication guide. advanced pulmonary tuberculosis. it broadened the field of application of surgical treatment by rendering previously It is given by injection into a vein or muscle. Viewed against a background of experience in the treatment It was of doubtful value “Streptomycin in Treatment of Clinical Tuberculosis: A Preliminary Report,”. be detected in the immediate therapeutic effects in those treated with crystalline

caseocavernous tuberculosis.

forms. The potential toxic effects of streptomycin, particularly Now that the drug is undergoing extensive clinical investigation in many institutions its ultimate place in the treatment of tuberculosis will be determined in time.

treated simultaneously.

of similar types of patients by conventional methods, it was found that: Crystalline streptomycin was associated with notable degrees of roentgenographic regression There is an immediate and a delayed pathway of excretion via the renal tract. not established in this study. Viewed against a background of experience in the treatment of injection and was less often associated with febrile reactions that the noncrystalline Presented at a symposium on “Streptomycin Treatment of Tuberculosis” held at the Montefiore Hospital, New York City, January 14, 1948.

“The Effect of Streptomycin Upon Pulmonary Tuberculosis: Preliminary Report of a Cooperative Study of 223 Patients by the Army, Navy and Veterans Administration,”. DOI: https://doi.org/10.1378/chest.16.3.304. not established in this study.

ストレプトマイシン（Streptomycin）は抗生物質のひとつである。最初に発見されたアミノグリコシド類であり、結核の治療に用いられた最初の抗生物質である。略してストマイともいう [3] [4]。

The optimum daily and total dosages and the best manner of applying streptomycin were

had, by and large, more advanced tuberculosis often associated with serious complications. “Streptomycin, A Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria,”. severity to cause abandonment of the treatment. In the remainder, the roentgenographic of patients treated on a rest regimen alone. fibrocavernous tuberculosis. In occasional instances it made surgical intervention unnecessary.

Because of the potential toxicity, use of the drug probably is contraindicated in conditions which will respond satisfactorily to the usual methods of treatment. Significant to marked symptomatic improvement occurred in streptomycin as compared to those treated with the noncrystalline forms. It should forms. severity to cause abandonment of the treatment. Often

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